Neurobiology research involves the mechanisms of neuronal cell death and neoplasia.

Neuropathology research is focused on understanding the pathogenesis of some of the most physically and emotionally devastating human illnesses including Alzheimer’s disease, Parkinson’s disease, drug abuse, brain tumors, schizophrenia and depression.  Typical graduate student research projects utilize modern molecular, biochemical, and neurobiological techniques to investigate the mechanisms of neurological and psychiatric disease pathogenesis.

• UAB Alzheimer's Disease Center
• UAB Alzheimer's Disease Research Center Funded for Another Five Years
• UAB to Coordinate National Group Seeking Neurofibromatosis Breakthrough
• $5 Million Grant to Create UAB Alzheimer's Center
• UAB Receives Brain Tumor SPORE: $11.5 Million Grant to Develop New Therapies

Molecular & Cellular Pathology
Neurobiology Research Faculty

Carroll, Steven, M.D., Ph.D.

Research Focus: Neuregulin-1 in nervous system regeneration and neoplasia

Select Highlights and Articles:

• Interactions between Beta-Neuregulin and Neurotrophins in Motor Neuron Apoptosis
• Neuregulin-1 Enhances Survival of Human Astrocytic Glioma Cells
• Improved Gene Delivery into Neuroglial Cells Using a Fiber-Modified Adenovirus Vector
• Neuregulin-1 Beta Induces Neurite Extension and Arborization in Cultured Hippocampal Neurons
• ErbB Transmembrane Tyrosine Kinase Receptors Are Expressed by Sensory and Motor Neurons Projecting into Sciatic Nerve

Gladson, Candece, M.D.

Research Focus: Malignant astrocytoma cell migration

Select Highlights and Articles:

• Syndecan-2 Is Expressed in the Microvasculature of Gliomas and Regulates Angiogenic Processes in Microvascular Endothelial Cells
• A Novel Technique to Quantify Glioma Tumor Invasion Using Serial Microscopy Sections
• Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors
• Lyn Kinase Activity Is the Predominant Cellular Src Kinase Activity in Glioblastoma Tumor Cells
• Endogenous Inhibitors of Angiogenesis in Malignant Gliomas: Nature's Antiangiogenic Therapy

Roth, Kevin, M.D., Ph.D.

Research Focus: Molecular regulation of neuronal cell death

Select Highlights and Articles:

• Tissue Transglutaminase Overexpression in the Brain Potentiates Calcium-Induced Hippocampal Damage
• Bafilomycin A1 Inhibits Chloroquine-Induced Death of Cerebellar Granule Neurons
• Cathepsin Deficiency As a Model for Neuronal Ceroid Lipofuscinoses
• Role of Caspase-3 in Ethanol-Induced Developmental Neurodegeneration
• Bax Deletion Prevents Neuronal Loss but Not Neurological Symptoms in a Transgenic Model of Inherited Prion Disease