Gene therapy represents a novel approach to human disease based
on direct employment of nucleic acids as medicine.
Gene therapy is the transfer of genetic material to
the cells of an individual for therapeutic purposes. Successful human gene
therapy depends on the development of gene delivery vehicles, or vectors,
capable of mediating safe and efficient gene transfer to target cells.
Current research investigates the use of gene therapy for
inherited disorders, infectious disease, autoimmune disorders, and chronic
acquired disorders, such as cancer and coronary artery disease. Typical research
projects for graduate students involve designing novel vectors and testing their
efficacy in animal models of human diseases.
Molecular and Cellular Pathology
Gene Therapy Research
Faculty
Douglas, Joanne, Ph.D.
Research Focus: Gene therapy; adenoviral vectors;
conditionally replicating adenoviruses
Select Highlights and
Articles:
Krasnykh, Victor Ph.D.
Research Focus: Gene therapy directed at tumor
vasculature
Select Highlights and
Articles:
Ponnazhagan, Selvarangan, Ph.D.
Research Focus: Adeno-associated virus gene therapy
Select Highlights and
Articles:
Siegal,
Gene, M.D., Ph.D.
Research Focus: Gene therapy of solid tumors
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Highlights and Articles:
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