Gladson, Candece, M.D.

Research Focus: Malignant astrocytoma cell migration

Select Highlights and Articles:

• UAB Receives Brain Tumor SPORE: $11.5 Million Grant to Develop New Therapies
• Syndecan-2 Is Expressed in the Microvasculature of Gliomas and Regulates Angiogenic Processes in Microvascular Endothelial Cells
• A Novel Technique to Quantify Glioma Tumor Invasion Using Serial Microscopy Sections
• Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors
• Lyn Kinase Activity Is the Predominant Cellular Src Kinase Activity in Glioblastoma Tumor Cells
• Endogenous Inhibitors of Angiogenesis in Malignant Gliomas: Nature's Antiangiogenic Therapy

Kucik, Dennis, M.D., Ph.D.

Research Focus: Cell adhesion and motility

Select Highlights and Articles:

• Both Th1 and Th2 Cells Require P-selectin Glycoprotein Ligand-1 for Optimal Rolling on Inflamed Endothelium
• Revealing Anti-inflammatory Mechanisms of Soy Isoflavones by Flow: Modulation of Leukocyte-Endothelial Cell Interactions
• Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent Pathway
• Avidity Modulation Activates Adhesion under Flow and Requires Cooperativity among Adhesion Receptors
• Thrombospondin Signaling through the Calreticulin/LDL Receptor-related Protein Co-complex Stimulates Random and Directed Cell Migration

Murphy-Ullrich, Joanne, Ph.D.

Research Focus: Regulation of cell death and motility by cell adhesion signaling and role of growth factor control in diabetic and fibrotic diseases

Select Highlights and Articles:

• Cell Adhesion and Matrix Research Center: Unraveling the Complexities of Tissue Fibrosis
• CAMRC Expands Translational Possibilities: FRET Microscopy Core Facility Launched 
• Thrombospondin I Mediates Angiotensin II Induction of TGF-Beta Activation by Cardiac and Renal Cells under Both High and Low Glucose Conditions
• Glutathione Restores Collagen Degradation in TGF-Beta-treated Fibroblasts by Blocking Plasminogen Activator Inhibiitor-1 Expression and Activating Plasminogen
• Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte
• Endothelin-A Receptor Blockade Prevents and Partially Reverses Neonatal Hypoxic Pulmonary Vascular Remodeling
• Transducible Heat Shock Protein 20 (HSP20) Phosphopeptide Alters Cytoskeletal Dynamics