Our lab studies 2 metastasis suppressor genes, Breast Cancer Metastasis
Suppressor 1 (BRMS1) and
KISS-1. |
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Hometown:
Pune,
India
Undergraduate/Masters Institution:
Byramjee
Jeejeebhoy Medical College
Pune, India
General Research
Interests:
Cancer
Biology
|
| These genes have been shown to
suppress lung metastasis in animal models using human breast cancer and melanoma
cell lines. Their ability to suppress bone metastasis, the commonest site of
spread in breast cancer has not been tested and is my primary research focus. My
experiments have shown that BRMS1 not only suppresses metastasis to bone, but
also the brain, pancreas, kidneys, adrenals and gastrointestinal tract
(Manuscript in preparation). As a prelude to these studies, I performed a series
of experiments to understand the trafficking of breast cancer cells in the early
stages of bone metastasis. While single cells were detected an hour after
injection, the more surprising result was the near obliteration of osteoblasts
at 4 weeks, with little change in osteoclast number. This manuscript has been
accepted in Clinical Cancer Research. |
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