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Hometown:
Nagpur,
India
Undergraduate/Masters Institution:
Indian
Institute of Technology, India
General Research
Interests:
Bone
metabolism
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| Although insulin signaling is well
studied in many tissues and cell types, a little is known about its role in
regulating bone metabolism. The study of insulin-specific signaling is
complicated by cross-activation of insulin receptor (IR) and insulin-like growth
factor-1 (IGF-1) receptor (IGF-1R) by both insulin and
IGF-1. |
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We have developed a system to knockout IR, IGF-1R or both specifically in
osteoblasts in mice which presents an opportunity to study independent roles of
insulin and IGF-1 in bone metabolism and remodeling. |
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