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Hometown:
Seoul,
Korea
Undergraduate/Masters Institution:
Ewha
Woman's University, M.S.
General Research
Interests:
Osteoblast differentiation,
Bone
biology
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NFAT (Nuclear factor of activated T cells), the family of transcription
factor, is the important transcription factor in many cellular systems,
including immune system and osteoclast differentiation.
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| We study the calcineurin/NFAT
singaling pathway which plays a role to regulate osteoblast differentiation by
modulating the expression and activation of AP-1 transcription factor members.
When we inhibit calcineurin/NFAT signaling pathway by Cyclosporin A, a well
known immunosuppressive agent, it increases osteoblast differentiation in vivo
and in vitro by increasing fra-2 expression. In addition, we examine how the
calcineurin/NFAT signaling pathway regulates bone formation in animal
model. |
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