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Pathology Graduate Student Profiles | Next
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After two years of running clinical
studies and three years as a computer geek, I finished my undergrad degree and
took a 50% pay cut to become a Ph.D. student. Why? Because I can't imagine doing
something that I don't love for the next 20 years and trading time for
money.
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Hometown:
San
Diego, CA;
originally Taipei, Taiwan
Undergraduate/Masters
Institution:
University of California, San
Diego
General Research Interests:
Mitochondria,
Free radicals
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Cardiovascular disease (CVD) is the
leading cause of death in the United States, and atherosclerosis is a major risk
factor for CVD. Free radicals have been implicated in atherosclerosis
development, yet anti-oxidant treatments have been unsuccessful. Recent research
demonstrates free radicals as mediators of cell signaling, and that its presence
confer positive effects, such as pre-conditioning protection against
ischemia/reperfusion injury.
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Using the ApoE-/- mouse atherosclerosis model and pollutants such as tobacco
smoke, we study the mitochondria's dual role as both target and source of free
radicals, as well downstream effects such as protein
modification. |
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