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| Primary Name |
Factor VIII Inhibitor Titer |
| Synonym |
Bethesda Titer for Factor VIII Inhibitor |
| Synonym |
-- |
| Contraction |
FVIII Inhibitor |
| Contraction |
FVIII Inh |
| Contraction |
-- |
| UAB Procedure Number |
2500490 |
| CPT Code |
85730, 85732, 85240, 85335 |
| Specimen |
Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. |
| Specimen Management |
Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. |
| Specimen Accepted |
Daily including weekends |
| Times Available |
0730-1600; deliver to lab by 1300 for same-day results |
| Test Performed |
Monday-Friday. |
| Available Stat? |
Pathologist's approval required. |
| Description |
Factor VIII inhibitors are IgG alloantibodies specific for therapeutic factor VIII. Factor VIII inhibitors appear in 22 to 33% of severe hemophilia patients. Inhibitors typically neutralize therapeutic factor VIII concentrates making it necessary to provide patients with alternative therapy. Autoimmune anti-factor VIII antibodies may arise in rare circumstances, causing acquired hemophilia, with severe bleeding. |
| Reference Interval |
None detected |
| Critical Value |
-- |
| Therapeutic Range |
-- |
| Follow-up Test |
Low-titer factor VIII inhibitor assays are also available; contact the special coagulation laboratory. |
| Associated With |
Bleeding disorders |
| Associated With |
Coagulation factor inhibitors |
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