Factor V Leiden Mutation

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Primary Name	Factor V Leiden mutation
Synonym	Factor V gene mutation
Synonym	Leiden gene mutation
Contraction	FVL
Contraction	Occasionally confused with factor V activity
Contraction	--
UAB Procedure Number	3503050
CPT Code	83891, 83892, 83896´2, 83903´2, 83912
Specimen	*Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume for APC resistance assay.Do not underfill or overfill. Also collect one (1) lavender-stopper tube (EDTA) whole blood. Do not centrifuge.
Specimen Management	Centrifuge blue-stopper tube within one (1) hour of collection, separate plasma and test or quick-freeze at -70°C. If follow-up factor V Leiden mutation test is indicated, the uncentrifuged lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice.
Specimen Accepted	Daily including weekends
Times Available	0730-1600
Test Performed	Factor V Leiden assay performed by reference laboratory. Results available in five days.
Available Stat?	Pathologist's approval required.
Description	If the factor V Leiden mutation assay is ordered without the APC resistance test, the UAB Coagulation Service substitutes the APC resistance test as a screen. APC resistance is a thrombotic risk factor caused by the factor V Leiden mutation that is present in 3 to 8% of Caucasians. Factor V Leiden mutation confers a 2 to 8-fold increased risk of venous thrombosis.
Reference Interval	Negative. A pathology interpretation accompanies the report.
Critical Value	--
Therapeutic Range	--
Follow-up Test	--
Associated With	Venous thrombosis