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| Primary Name |
Lupus Anticoagulant Profile |
| Synonym |
Non-specific inhibitor |
| Synonym |
-- |
| Contraction |
LAC |
| Contraction |
LA |
| Contraction |
-- |
| UAB Procedure Number |
2500310, 2500725, 2500359, 2500305 |
| CPT Code |
85730, 85732, 85613, 85597 |
| Specimen |
Collect three (3) blue-stopper tubes (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. |
| Specimen Management |
Centrifuge blue-stopper tubes within one (1) hour of collection, separate plasma. Recentrifuge plasma so that it is platelet-poor and test or quick-freeze at -70°C. |
| Specimen Accepted |
Daily including weekends |
| Times Available |
0730-1600 |
| Test Performed |
Two days a week |
| Available Stat? |
Pathologist's approval required. |
| Description |
LAC is an acquired non-specific inhibitor that is detected in 1-2% of individuals. Chronic lupus anticoagulant is associated with a 30% risk of venous thromboembolic disease or arterial thrombosis, including stroke and myocardial infarction. LAC is also associated with chronic spontaneous abortion. |
| Reference Interval |
A pathology interpretation is provided with all reports. When normal, the report is the following phrase: "There is no evidence of lupus anticoagulant (LAC) by two screening tests (PTT-LA and DRVVT). Unless there is a clinical suspicion, no further testing for LAC is indicated." |
| Critical Value |
-- |
| Therapeutic Range |
-- |
| Follow-up Test |
*The lupus anticoagulant profile is a series of clotting assays based on the PTT-LA and the DRVVT with follow-up mixing studies and neutralization stages.
*A positive lupus anticoagulant profile should be repeated on a new specimen after 12 weeks to determine if the inhibitor is transient or chronic.
*The anticardiolipin antibody and the anti-beta2-glycoprotein I immunoassays are recommended for a complete workup of possible antiphospholipid syndrome.
*The diagnosis of antiphospholipid antibidy syndrome requires a clinical history of thrombosis and a positive laboratory test for LAC or anticardiolipin antibodies that persist for 12 weeks. |
| Associated With |
Venous thrombosis |
| Associated With |
Arterial thrombosis |
| Associated With |
Lupus anticoagulant |
| Associated With |
Spontaneous abortions |
| Associated With |
Coagulation factor inhibitors |
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