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| Primary Name |
ADAMTS13 |
| Synonym |
Von Willebrand factor cleaving protease |
| Synonym |
Test for thrombotic thrombocytopenic purpura |
| Contraction |
VWF cleaving protease |
| Contraction |
-- |
| Contraction |
-- |
| UAB Procedure Number |
-- |
| CPT Code |
85246, 85335 |
| Specimen |
Collect two (2) blue-stopper tubes (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. |
| Specimen Management |
Centrifuge blue-stopper tubes within one (1) hour of collection, separate plasma and test or quick-freeze at -70°C. |
| Specimen Accepted |
Daily including weekends |
| Times Available |
Specimen accepted between 0730-1600 |
| Test Performed |
Assay is performed by reference laboratory. Results available in ten days. |
| Available Stat? |
Not available stat as it is a sendout. Pathologist's approval required. |
| Description |
ADAMTS13 is an enzyme of the family identified as "a disintegrin and metalloprotease with thrombospondin type-1 motifs." It's more common name is von Willebrand factor cleaving protease. The ADAMTS13 assay may be used to distinguish chronic recurring thrombotic thrombocytopenic purpura (TTP), TTP secondary to the presence of ADAMTS13 inhibitor, and hemolytic-uremic syndrome (HUS). |
| Reference Interval |
ADAMTS13 is normally present in plasma. It is reduced in recurring TTP and in TTP due to the presence of an inhibitor, which may be demonstrated in the inhibitor portion of the assay. ADAMTS13 is present in HUS. |
| Critical Value |
-- |
| Therapeutic Range |
-- |
| Follow-up Test |
-- |
| Associated With |
Thrombotic thrombocytopenic purpura |
| Associated With |
-- |
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