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| Primary Name |
Anticardiolipin IgM Antibody |
| Synonym |
Anticardiolipin antibody |
| Synonym |
Antiphospholipid antibody |
| Contraction |
ACA |
| Contraction |
ACL |
| Contraction |
-- |
| UAB Procedure Number |
|
| CPT Code |
86147 |
| Specimen |
Collect one serum separator tube (Vacutainer SST with tiger top) with a gel barrier. Minimum volume 2 mL. |
| Specimen Management |
Centrifuge tube within one (1) hour of collection, separate serum and test or freeze at -70°C. |
| Specimen Accepted |
Daily including weekends |
| Times Available |
0730-1600 |
| Test Performed |
One day a week |
| Available Stat? |
No |
| Description |
ACAs are acquired non-specific inhibitors that are detected in 1-2% of individuals. Chronic ACA is associated with a 30% risk of venous thromboembolic disease or arterial thrombosis, including stroke and myocardial infarction. Chronic ACA is also associated with chronic spontaneous abortion. |
| Reference Interval |
Negative: 10 MPL units/mL or less
Low positive: 11-20 MPL units/mL
Moderate positive: 21-60 MPL units/mL
High positive: More than 60 MPL units/mL |
| Critical Value |
-- |
| Therapeutic Range |
-- |
| Follow-up Test |
*The ACA is recommended as part of a complete workup for possible antiphospholipid syndrome. It should be accompanied by the lupus anticoagulant profile.
*The lupus anticoagulant profile is a series of assays based on the PTT-LA and the DRVVT with follow-up mixing studies and neutralization stages.
*A positive lupus anticoagulant profile or ACA should be repeated on a new specimen after 8-10 weeks to determine if the inhibitor is transient or chronic.
* Other assays associated with ACA and lupus anticoagulant testing are the beta-2 glycoprotein 1 antibody and the anti-prothrombin antibody test. |
| Associated With |
Venous thrombosis |
| Associated With |
Arterial thrombosis |
| Associated With |
Lupus anticoagulant |
| Associated With |
Spontaneous abortions |
| Associated With |
Coagulation factor inhibitors |
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